Endocrine Abstracts

Introduction: The association of primary hyperparathyroidism (PHPT) and hyperthyroidism secondary to toxic multinodular goiter (TMNG) is rarely described in the literature. Hereby, we describe the clinical, biological, and radiological characteristics of two patients having this rare association.Observations: First case: A 66 years-old female was diagnosed with primary hyperthyroidism. Her thyroid antibodies were negatives. During the follow-up, she pres...

Autoimmune thyroid diseases (AITD), which include Hashimoto thyroiditis (HT), Graves’ disease (GD) and primary idiopathicmyxoedema (PIM), are recognized by their clinical and genetic heterogeneity. In this study, we have carried on a global approach gathering 20 year genetic and clinical data on a Tunisian multigenerational family (Akr). Our purpose was search for a combined genotype involved in AITD susceptibility using 33 gene polymorphisms. The Akr pedigree is composed...

We aimed to identify causal mutation(s) in 13 patients with thyroid dyshormonogenesis (TD) from three consanguineous Tunisian families. A 12-year clinical follow-up showed phenotypic variability ranging from the presence to the absence of goiter, sensorineural deafness, and mental retardation. Genetic analysis using microsatellite markers within two candidate genes (TPO and PDS) gave evidence of linkage with the TPO gene. Sequencing of its 17 exons and their flanking intron-ex...

Introduction Multiple autoimmune syndrome (MASI) is a rare entity, defined by the presence of at least three autoimmune diseases in the same person. We report two specific observations of myasthenia gravis in the context of an SAIM3. Observation 1 A 58-year-old man initially presented bilateral ptosis, difficulty chewing and swallowing, dysphonia and fatigability. Myasthenia gravis was suspected due to the ag...

Introduction: The chrono-type, intrinsic to each individual, is the tendency of an individual to prefer activities carried out in the morning or evening. The aim of our study was to determine the chronotype of our obese patients.Materials and methods: This is a descriptive cross-sectional study involving obese adults consulting the service of Endocrinology of Sfax, Hedi Chaker University Hospital, during the period extending from December 2022 until Marc...

Introduction: Diabetic neuropathy is the most common cause of neuropathy worldwide and is known to affect approximately half of all diabetic patients. It significantly impairs the quality of life of patients.Aim of the study: To establish the predictive factors of distal symmetric polyneuropathy (DSPN) in diabetic patients.Methods: This is a descriptive cross-sectional study including 116 patients. The diagnosis of PNDS was establi...

Introduction: The prevalence of diabetes in the world population is increasing day by day so that its frequency reaches epidemic proportions. As a result, the complications of diabetes are becoming more and more frequent. Diabetic neuropathy, the most common complication which affect up to half of the patients.Purpose of the study: To establish the prevalence of distal symmetrical polyneuropathy (DSPN) in diabetic patients and demonstrate the importance ...

Introduction: The diagnosis of insulinomas is made biochemically. However, proper localization of insulinomas is essential before surgery. Therefore, we aimed to evaluate the role of different imaging techniques in the localization of insulinomas. Case series: This case series include 10 patients with biochemically proven insulinomas. The age, gender, results of MRI, CT, EUS, are shown in Table-1. In imaging investigations, abdominal ultrasonography (AU)...

Introduction: Insulinoma is a rare neuroendocrine tumor with an incidence of 1 to 4 per million person-years. It is the most frequent endocrine tumor of the pancreas and is revealed by a spontaneous hypoglycemia. This study aimed to determine the clinical characteristics, diagnostic workup, and outcome of patients with insulinoma.Methods: This is a descriptive, retrospective study including patients with confirmed insulinoma collected over a 32-year peri...

Background and Aims: Cardiometabolic comorbidity is a well-established complication related to GH hypersecretion. Several studies have highlighted an increased cardiovascular risk in this population. The objective of the current work was to investigate the cardiovascular complications in Tunisian patients diagnosed with acromegaly.Patients and Method: We conducted a retrospective study that included all patients diagnosed with acromegaly who have been fo...